Prof. Valle is a distinguished medical oncologist based at The Christie NHS Foundation Trust, specialising in the treatment of gastrointestinal cancers. He has been a pivotal member of the gastrointestinal disease group since his appointment. Prof. Valle's areas of expertise include cancers of the pancreas, liver, biliary tract, neuroendocrine tumours, and colorectal cancer.

As the lead clinician of The Christie's neuroendocrine tumour service, Prof. Valle has played a crucial role in the service being awarded the European Centre of Excellence status in March 2011. His dedication to advancing medical oncology is further demonstrated through his active involvement in the UK National Cancer Research Network (NCRN). He is a member of the upper gastrointestinal clinical studies group and a co-founding member of the cholangiocarcinoma working party. Additionally, he contributes to the NCRN pancreatic cancer, hepatopancreatobiliary, and neuroendocrine subgroups.

Prof. Valle's commitment to research is evident through the numerous grants he has been awarded, leading to a wealth of publications and presentations at both national and international meetings. He is also a respected peer reviewer for several international medical journals.

His professional affiliations include membership in the American Society of Clinical Oncology (ASCO), the European Society of Medical Oncology (ESMO), the UK and Ireland Neuroendocrine Tumour Society (UKI NETS), and the European Neuroendocrine Tumour Society (ENETS).

Prof. Valle's clinical expertise encompasses a wide range of conditions and treatments, including:

- Upper gastrointestinal (GI) cancer
- Hepatopancreatobiliary (HPB) cancer
- Pancreatic cancer
- Hepatocellular carcinoma
- Biliary tract cancer
- Cholangiocarcinoma
- Gall bladder cancer
- Ampullary tumour
- Liver cancer
- Colorectal cancer
- Neuroendocrine cancer

Prof. Valle's dedication to patient care and his contributions to the field of medical oncology make him a highly respected and sought-after specialist in his field.